A clinically useful approach to enhance immunological memory and antitumor immunity
نویسندگان
چکیده
Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014